butabarbital raises outcomes of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. CYP3A4 inducers may perhaps enhance the metabolism of ifosfamide to its active alkylating metabolites.butabarbital will lessen the level or outcome of oliceridine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use War